- Axsome Therapeutics Bets on AUVELITY Expansion With June Alzheimer's Agitation Launch
May 12, 2026 · marketbeat.com
Axsome Therapeutics NASDAQ: AXSM executives said the company is preparing for a June launch of AUVELITY in Alzheimer's disease agitation while continuing to expand its push in major depressive disorder, citing broad payer access, a larger sales force and what they described as a differentiated clinical profile.
- Axsome Therapeutics, Inc. (AXSM) Presents at Bank of America Global Healthcare Conference 2026 Transcript
May 12, 2026 · seekingalpha.com
Axsome Therapeutics, Inc. (AXSM) Presents at Bank of America Global Healthcare Conference 2026 Transcript
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- Assessing Axsome Therapeutics (AXSM) Valuation After Strong Recent Share Price Momentum
May 7, 2026
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Axsome Therapeutics: Stock Performance Snapshot
Axsome Therapeutics (AXSM) stock has attracted investor attention after a strong run, with the share price at US$222.63 and total return figures over the past year and past 3 months drawing closer scrutiny.
See our latest analysis for Axsome Therapeutics.
The recent 7 day share price return of 21.03% and 30 day share price return of 31.16%, alongside a 1 year total shareholder return of 100.82%, point to momentum that has built over time rather than a short term spike.
If Axsome's move has you thinking about other healthcare opportunities tied to advanced technology, it may be worth scanning a wider field of 32 healthcare AI stocks
With Axsome's shares at US$222.63, a value score of 3, an intrinsic value estimate that suggests a sizable discount, and analyst targets set higher, the key question is whether there is still an opportunity here or if the market is already pricing in potential future developments.
Most Popular Narrative: 16.6% Undervalued
Axsome's most followed narrative points to a fair value of $266.94, above the last close at $222.63. This sets up a valuation story built around future earnings power under a 7.11% discount rate.
The company is advancing multiple late-stage clinical programs (AXS-05, AXS-12, AXS-14, and several solriamfetol indications), which positions Axsome to benefit from the aging population and rising prevalence of CNS disorders, potentially resulting in a diversified revenue base, higher earnings, and reduced risk of overreliance on a single product.
Read the complete narrative.
Want to see what kind of revenue ramp and margin shift that portfolio build out assumes? The narrative leans on aggressive compounding, stronger profitability, and a richer future earnings multiple to justify its fair value path.
Result: Fair Value of $266.94 (UNDERVALUED)
Have a read of the narrative in full and understand what's behind the forecasts.
However, this depends on Auvelity and Sunosi continuing to generate most of the revenue, while ongoing net losses and high spending leave little room for setbacks.
Find out about the key risks to this Axsome Therapeutics narrative.
Another Way to Look at Valuation
The earlier view leans on future cash flows and points to Axsome trading 72.1% below an internal fair value estimate of $798.52. Yet on a simpler P/S basis, the stock looks expensive at 16.2x versus 5.5x for the US Pharmaceuticals industry, 9.2x for peers, and a 15.5x fair ratio that the market could move toward. For you, that raises a simple question: is this a discount on future cash flows or a premium on today’s sales?
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See what the numbers say about this price — find out in our valuation breakdown.NasdaqGM:AXSM P/S Ratio as at May 2026
Next Steps
With mixed signals on valuation and growth potential, this is a moment to look at the data yourself and decide where you stand. If the optimism around Axsome's prospects has caught your eye, take a closer look at the 3 key rewards
Ready to hunt for more investment ideas?
If Axsome has sharpened your focus, do not stop here. Widen your watchlist with other focused ideas that could suit your goals and risk comfort.
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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.
Companies discussed in this article include AXSM.
Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com
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- Axsome Therapeutics Recognizes Mental Health Month
May 7, 2026
Axsome Therapeutics, Inc.
NEW YORK, May 07, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) disorders, today announced its support for Mental Health Month alongside the broader mental health advocacy community. In recognition of this year’s More Good Days Together theme, Axsome is sharing resources to support individuals affected by mental health conditions, their families, and the communities around them.
“At Mental Health America, we are proud to have established Mental Health Month in 1949, with the goal of educating the public about mental illness, mental health, and recovery,” said Pierluigi Mancini, PhD, interim president and CEO of Mental Health America (MHA). “Our 2026 campaign, More Good Days, Together, provides tools and resources that meet people where they are, support them as whole people, and acknowledge that 'good' is defined by their unique experience and goals. The path may look different for everyone, but we all deserve more good days, together."
Mental health conditions are highly prevalent in the U.S., with nearly 1 in 4 adults living with a mental illness.1 Major depressive disorder (MDD), one of the most common mental health conditions, is a leading cause of disability worldwide and impacts over 21 million adults in the U.S. alone.1-3 Nearly 90% of people living with depression report difficulty with work, home, or social activities due to their symptoms, underscoring the impact depression can have on day-to-day life.4
Axsome’s mission is to develop and deliver transformative medicines to improve the brain health of millions of individuals affected by central nervous system conditions, including those living with difficult-to-treat mental illness. To help raise awareness and promote action during Mental Health Month, Axsome is highlighting non-profit organizations and resources that provide education, tools, and community support for individuals and families affected by mental health conditions, including:
2026 Mental Health Month Action Guide (https://mhanational.org/2026-mental-health-month-action-guide/) MHA’s work is driven by its commitment to promote mental health as a critical part of overall wellness, including prevention services for all; early identification and intervention for those at risk; and integrated care, services, and support for those who need them, with recovery as the goal. Its 2026 Mental Health Month Action Guide provides access to online activities, articles, printable tools, and practical resources Anxiety and Depression Association of America (ADAA)’s “Find Your Therapist” platform (https://findyourtherapist.adaa.org/) helps connect people with licensed mental health professionals who specialize in treating anxiety, depression, OCD, PTSD, and other related disorders. This aligns with ADAA’s 2026 annual conference theme around “Innovations in Technology Driving Clinical Care and Research in Mood and Anxiety Disorders,” and the organizations commitment to improving live through collaboration, research, education, and innovation. The National Alliance on Mental Illness (NAMI) New York Chapter (https://naminycmetro.org/), guided by lived experience and evidence-based practices, helps families and individuals affected by mental illness build better lives through education, support, and advocacy. Later this month NAMI-NYC is hosting its annual Mental Health Street Fest, which is the nation’s largest mental health event, being held since 2007: https://www.namiwalks.org/nyc.
Story Continues
If you or someone you know is in crisis, the 988 Suicide & Crisis Lifeline (https://988lifeline.org/) is a free confidential support service available 24 hours a day, 7 days a week across the United States. When people call, text, or chat 988, they will be connected to trained counselors that are part of the existing Lifeline network. These trained counselors will listen, understand how their problems are affecting them, provide support, and connect them to resources if necessary.
About Axsome Therapeutics
Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, agitation associated with dementia due to Alzheimer’s disease, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, as well as multiple novel product candidates addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X.
Forward Looking Statements
Certain matters discussed in this press release are “forward-looking statements”. The Company may, in some cases, use terms such as “predicts,” “believes,” “potential,” “continue,” “estimates,” “anticipates,” “expects,” “plans,” “intends,” “may,” “could,” “might,” “will,” “should” or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. In particular, the Company’s statements regarding trends and potential future results are examples of such forward-looking statements. The forward-looking statements include risks and uncertainties, including, but not limited to, the commercial success of the Company’s SUNOSI®, AUVELITY®, and SYMBRAVO® products and the success of the Company’s efforts to obtain any additional indication(s) with respect to solriamfetol and/or AXS-05; the Company’s ability to maintain and expand payer coverage; the success, timing and cost of the Company’s ongoing clinical trials and anticipated clinical trials for the Company’s current product candidates, including statements regarding the timing of initiation, pace of enrollment and completion of the trials (including the Company’s ability to fully fund the Company’s disclosed clinical trials, which assumes no material changes to the Company’s currently projected revenues or expenses), futility analyses and receipt of interim results, which are not necessarily indicative of the final results of the Company’s ongoing clinical trials, and/or data readouts, and the number or type of studies or nature of results necessary to support the filing of a new drug application (“NDA”) for any of the Company’s current product candidates; the Company’s ability to fund additional clinical trials to continue the advancement of the Company’s product candidates; the timing of and the Company’s ability to obtain and maintain U.S. Food and Drug Administration (“FDA”) or other regulatory authority approval of, or other action with respect to, the Company’s product candidates, including statements regarding the timing of any NDA submission; the Company’s ability to successfully defend its intellectual property or obtain the necessary licenses at a cost acceptable to the Company, if at all; the Company’s ability to successfully resolve any intellectual property litigation, and even if such disputes are settled, whether the applicable federal agencies will approve of such settlements; the successful implementation of the Company’s research and development programs and collaborations; the success of the Company’s license agreements; the acceptance by the market of the Company’s products and product candidates, if approved; the Company’s anticipated capital requirements, including the amount of capital required for the commercialization of SUNOSI, AUVELITY, and SYMBRAVO and for the Company’s commercial launch of its other product candidates, if approved, and the potential impact on the Company’s anticipated cash runway; the Company’s ability to convert sales to recognized revenue and maintain a favorable gross to net sales; unforeseen circumstances or other disruptions to normal business operations arising from or related to domestic political climate, geo-political conflicts or a global pandemic and other factors, including general economic conditions and regulatory developments, not within the Company’s control. The factors discussed herein could cause actual results and developments to be materially different from those expressed in or implied by such statements. The forward-looking statements are made only as of the date of this press release and the Company undertakes no obligation to publicly update such forward-looking statements to reflect subsequent events or circumstances.
Investors:
Ashley Dong
Senior Director, Investor Relations
(929) 687-1614
adong@axsome.com
Media:
Darren Opland
Senior Director, Corporate Communications
(929) 837-1065
dopland@axsome.com
References:
Substance Abuse and Mental Health Services Administration. Key Substance Use and Mental Health Indicators in the United States: Results from the 2023 National Survey on Drug Use and Health. July 2024. https://www.samhsa.gov/data/report/2023-nsduh-annual-national-report World Health Organization. Depression and Other Common Mental Disorders: Global Health Estimates. 2017.https://www.who.int/publications/i/item/depression-global-health-estimates National Institute of Mental Health. Major Depression. Accessed February 2026. https://www.nimh.nih.gov/health/statistics/major-depression Brody DJ, Hughes JP. Depression prevalence in adolescents and adults: United States, August 2021–August 2023. 2025 Apr; (527)1–11. DOI: https://dx.doi.org/10.15620/cdc/174579.
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- How The Axsome Therapeutics (AXSM) Story Is Shifting After Auvelity And AXS 05 Developments
May 7, 2026
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The Street’s updated fair value estimate for Axsome Therapeutics has shifted from US$223.99 to US$266.94, signaling a different view on potential upside built into current models. That reset is tied to fresh analyst work on Auvelity, the AXS-05 PDUFA decision for Alzheimer’s disease agitation, and how quickly the broader pipeline and indications might translate into cash generation. Below, you will see what is driving these shifting price targets and how to track the story as new data and regulatory events come through.
Stay updated as the Fair Value for Axsome Therapeutics shifts by adding it to your watchlist or portfolio. Alternatively, explore our Community to discover new perspectives on Axsome Therapeutics.
What Wall Street Has Been Saying
🐂 Bullish Takeaways
Firms including RBC Capital, UBS, Guggenheim, TD Cowen, Mizuho, BofA, Morgan Stanley, Oppenheimer, Piper Sandler, Jefferies, Cantor Fitzgerald, H.C. Wainwright, Baird, Needham and Morgan Stanley have raised Axsome Therapeutics price targets across multiple research updates, reflecting revised assumptions on the Auvelity franchise, AXS-05 in Alzheimer’s disease agitation and the broader pipeline. Several reports highlight Auvelity and AXS-05 as central to long term cash generation, with earlier commentary from RBC Capital, UBS, Guggenheim and Wells Fargo tying their target moves to expectations around operating leverage, label outcomes and potential commercial opportunities in Alzheimer’s disease agitation. Wolfe Research initiated coverage in February with a US$230 price target that was tied directly to a constructive view on Auvelity, adding another supportive voice to the coverage group on the lead asset.
🐻 Bearish Takeaways
Not every update has been positive. Deutsche Bank most recently trimmed its Axsome Therapeutics price target by US$1, which signals some caution around how prior assumptions on valuation, execution or timing might compare with current information. The spread in targets, including more measured stances such as Morgan Stanley’s Equal Weight rating in earlier research, suggests that while many analysts see attractive potential, there is still debate on execution risks, regulatory outcomes and how quickly Axsome’s portfolio can translate into sustained cash flow.
Do your thoughts align with the Bull or Bear Analysts? Perhaps you think there's more to the story. Head to the Simply Wall St Community to discover more perspectives!
Story Continues
NasdaqGM:AXSM 1-Year Stock Price Chart
See how Axsome Therapeutics' fair value stacks up across multiple valuation models — not just analyst targets.
How This Changes the Fair Value For Axsome Therapeutics
Fair value estimate moves from US$223.99 to US$266.94. Modeled long term revenue growth shifts from 48.84% to 51.76%. Projected net profit margin adjusts from 35.58% to 37.66%. Future P/E multiple changes from 20.87x to 20.40x. Discount rate moves from 6.98% to 7.11%.
Never Miss an Update: Follow The Narrative
Narratives link a company's clinical, commercial and financial story to a forecast and fair value that update as new information comes through. They help you see how product launches, trial results and risks fit together in one clear view.
Head over to the Simply Wall St Community and follow the Narrative on Axsome Therapeutics to stay up to date on:
How Auvelity, Sunosi and SYMBRAVO, together with late stage programs like AXS-05, AXS-12 and AXS-14, could broaden Axsome Therapeutics revenue base across CNS indications. What expanded payer coverage, commercial build out and precision neuroscience R&D might mean for product adoption and future margin trends. Key risks around reliance on a concentrated product set, high SG&A and R&D spending, pricing and reimbursement pressure, competition in CNS disorders and potential liquidity or dilution pressure if profitability is delayed.
This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.
Companies discussed in this article include AXSM.
Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com
View Comments
- Axsome Therapeutics Recognizes Mental Health Month
May 7, 2026 · globenewswire.com
NEW YORK, May 07, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) disorders, today announced its support for Mental Health Month alongside the broader mental health advocacy community. In recognition of this year's More Good Days Together theme, Axsome is sharing resources to support individuals affected by mental health conditions, their families, and the communities around them.
- AXSOME THERAPEUTICS RECOGNIZES MENTAL HEALTH MONTH
May 7, 2026
NEW YORK, MAY 07, 2026 (GLOBE NEWSWIRE) -- AXSOME THERAPEUTICS, INC. (NASDAQ: AXSM), A BIOPHARMACEUTICAL COMPANY LEADING A NEW ERA IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) DISORDERS, TODAY ANNOUNCED ITS SUPPORT FOR MENTAL HEALTH MONTH ALONGSIDE THE BROADER MENTAL HEALTH ADVOCACY COMMUNITY. IN RECOGNITION OF THIS YEAR'S MORE GOOD DAYS TOGETHER THEME, AXSOME IS SHARING RESOURCES TO SUPPORT INDIVIDUALS AFFECTED BY MENTAL HEALTH CONDITIONS, THEIR FAMILIES, AND THE COMMUNITIES AROUND THEM.
- Is Axsome Therapeutics (AXSM) Starting To Look Fully Priced After Its 1-Year Share Price Surge?
May 6, 2026
Find your next quality investment with Simply Wall St's easy and powerful screener, trusted by over 7 million individual investors worldwide.
Wondering whether Axsome Therapeutics at US$222.63 is starting to look expensive or if the price is still catching up to its story? This article breaks down what that current level might mean for value focused investors. The stock has moved sharply in recent periods, with returns of 21.0% over 7 days, 31.2% over 30 days, 24.6% year to date, 100.8% over 1 year, 177.5% over 3 years and 290.5% over 5 years. These moves are set against a backdrop of ongoing interest in pharmaceuticals and biotech companies focused on treatment development. Axsome Therapeutics is often discussed in relation to its pipeline and regulatory progress. News around clinical milestones, product approvals or partnership activity can quickly shift how investors think about both risk and opportunity for this stock. Simply Wall St currently gives Axsome Therapeutics a value score of 3 out of 6 based on its standard valuation checks. The rest of this article will unpack those traditional valuation approaches before turning to a broader way of thinking about what the stock might be worth in context.
Axsome Therapeutics delivered 100.8% returns over the last year. See how this stacks up to the rest of the Pharmaceuticals industry.
Approach 1: Axsome Therapeutics Discounted Cash Flow (DCF) Analysis
A Discounted Cash Flow, or DCF, model estimates what a stock might be worth by projecting future cash flows and then discounting those back to today’s value. It is essentially asking what those future dollars are worth in current terms.
For Axsome Therapeutics, the model used is a 2 Stage Free Cash Flow to Equity approach. The latest twelve month free cash flow is a loss of about $71.43 million. Analyst and extrapolated projections in the model suggest free cash flow turning positive in later years, reaching about $1.31 billion by 2030 in dollar terms, with intermediate annual figures ranging from roughly $61.25 million in outflows to over $2.26 billion in later projected inflows.
Discounting these projected cash flows back to today gives an estimated intrinsic value of about $798.52 per share. Compared with the recent share price of $222.63, this model-based estimate suggests the stock is 72.1% undervalued according to this DCF analysis.
Result: UNDERVALUED
Our Discounted Cash Flow (DCF) analysis suggests Axsome Therapeutics is undervalued by 72.1%. Track this in your watchlist or portfolio, or discover 47 more high quality undervalued stocks.
Story Continues
AXSM Discounted Cash Flow as at May 2026
Head to the Valuation section of our Company Report for more details on how we arrive at this Fair Value for Axsome Therapeutics.
Approach 2: Axsome Therapeutics Price vs Sales
For companies where earnings are limited or still being reinvested, the P/S ratio is often a useful way to think about value because it compares what you pay for each dollar of revenue rather than profit. Investors typically accept a higher or lower P/S depending on expectations for future growth and the level of business risk, so there is no single “right” multiple that fits every stock.
Axsome Therapeutics currently trades on a P/S of 16.18x. That sits above the Pharmaceuticals industry average of 5.47x and also above the peer average of 9.21x. Simply Wall St’s Fair Ratio framework estimates what an appropriate P/S might be for this stock, given factors such as growth profile, industry, profit margins, market cap and company specific risks, arriving at 15.55x.
This Fair Ratio can be more tailored than a simple comparison with peers or the industry, because it tries to align the multiple with Axsome Therapeutics' own fundamentals rather than broad group averages. Set against the current P/S of 16.18x, the Fair Ratio points to the stock trading at a premium to what this model suggests is warranted.
Result: OVERVALUEDNasdaqGM:AXSM P/S Ratio as at May 2026
P/S ratios tell one story, but what if the real opportunity lies elsewhere? Start investing in legacies, not executives. Discover our 20 top founder-led companies.
Upgrade Your Decision Making: Choose your Axsome Therapeutics Narrative
Earlier it was mentioned that there is an even better way to understand valuation. Narratives on Simply Wall St let you attach a clear story to your numbers by linking Axsome Therapeutics' business outlook to a concrete forecast and a Fair Value that you can compare with the current price. These update automatically when new earnings or news arrive, and can line up with very different viewpoints such as a more optimistic Axsome view with revenue growth of 64.6% a year, profit margins reaching 55.5% and a Fair Value of US$223.0, or a more cautious view using 40.2% revenue growth, 28.0% margins and a Fair Value of US$148.0. All of this is available inside the Community page so you can quickly see which story best matches your own expectations and whether that leaves the stock looking rich or cheap to you.
For Axsome Therapeutics however we will make it really easy for you with previews of two leading Axsome Therapeutics Narratives:
Start with the version that lines up most closely with your expectations, then sense check the assumptions on revenue, margins and valuation against your own view of the pipeline and risk.
🐂 Axsome Therapeutics Bull Case
Fair value used in this narrative: US$266.94 per share
Price vs this fair value: around 16.6% below that narrative fair value
Revenue growth used: 51.76% a year
Assumes Axsome builds on a broader CNS portfolio, with Auvelity, Sunosi and SYMBRAVO plus late stage assets helping to widen the revenue base over time. Bakes in higher revenue and margin expectations, with analysts modeling a move from current losses to earnings of US$932.4m by about 2029 and a future P/E of 20.6x. Treats current pricing, payer coverage and R&D investment as manageable risks that still support a fair value above the latest close.
🐻 Axsome Therapeutics Bear Case
Fair value used in this narrative: US$148.00 per share
Price vs this fair value: around 50.4% above that narrative fair value
Revenue growth used: 40.15% a year
Focuses on reliance on Auvelity and high anticipated discounts for key products, with concerns that pricing pressure and payer concessions could limit net revenue per prescription. Assumes the broad late stage pipeline and commercial build out keep R&D and SG&A high for longer, so earnings and margins improve but do not fully support the current share price. Uses a lower fair value of US$148.00, which reflects the more cautious analyst group that sees current market expectations as too optimistic even with revenue growth modeled at over 40% a year.
Do you think there's more to the story for Axsome Therapeutics? Head over to our Community to see what others are saying!NasdaqGM:AXSM 1-Year Stock Price Chart
This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.
Companies discussed in this article include AXSM.
Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com
View Comments
